Table 2.

Effect of treatment with AM6545 and/or perindopril on EC/EC‐related molecule levels and CB₁/CB₂ receptor mRNA ratio

	2‐AG (pmol·mg−1)	AEA (pmol·g−1)	PEA (pmol·mg−1)	OEA (pmol·mg−1)	CB1/CB2 mRNA ratio
ND	7.05 ± 0.46	2.44 ± 0.21	0.07 ± 0.01	0.21 ± 0.02	0.77 ± 0.14
DM	4.76 ± 0.55*	2.28 ± 0.71	0.09 ± 0.03	0.16 ± 0.02	2.12 ± 0.42*
DM‐ACE‐I	4.15 ± 1.36*	2.01 ± 0.16	0.10 ± 0.03	0.24 ± 0.05	1.98 ± 0.13*
DM‐AM6545	4.61 ± 0.36*	2.81 ± 1.46	0.18 ± 0.07	0.20 ± 0.05	2.14 ± 0.28*
DM‐Combo	4.55 ± 0.41*	2.82 ± 0.44	0.12 ± 0.06	0.16 ± 0.03	2.13 ± 0.44*

Data are shown as mean ± SEM; ACE‐I, treatment with perindopril; AM6545, treatment with AM6545; Combo, treatment with AM6545 plus perindopril.

^* P < 0.01 versus ND.