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. 2018 Nov 6;175(23):4310–4324. doi: 10.1111/bph.14487

Figure 4.

Figure 4

Effects of melittin on DNCB‐induced changes in the serum levels of IFN‐γ, IL‐4, IgE and TSLP, which were determined by ELISA kits (n = 5) (A). (B) Effects of melittin on DNCB‐induced IgE in splenocytes of Balb/c. The IgE level in cultured splenocytes was measured by ELISA (n = 5). (C) Real‐time PCR analyses show that melittin treatment inhibited the mRNA levels of IFN‐γ and IL‐4 (n = 5). *P < 0.05 versus NC; + P < 0.05 versus DNCB; ǂ P < 0.05 versus Pla; NC, normal control; DNCB, DNCB‐sensitized and challenged; Pla, placebo; Mel100, melittin 100 μg; Mel200, melittin 200 μg; Mel500, melittin 500 μg.