Table 1.

Characteristics of patients carrying SDH gene mutations.

	Patient one	Patient two	Patient three
Gene	SDHB	SDHB	SDHD
Gender/age	Male/14	Male/32	Female/45
Site	Post-caval	Para-aortic	Bifurcation of abdominal aorta
Size (cm)	5.1 × 3.4	3 × 2 × 2	2.9 × 2.7
Diagnosis	PGL	PGL	Hereditary PGL
Headache	+	–	–
Palpitation	+	–	+
Diaphoresis	+	–	–
Dizziness	–	–	+
Nausea	+	–	+
Hypertension (mmHg)	208/156	160/100	154/75
Nucleotide change	c.343C>T	c.541-2A>G	c.334_337delACTG
Mutation	P.Arg115Ter	IVS5-2A>G	p.Asp113Metfs*21
Mutation type	Detrimental mutation	Pathogenic	Pathogenic
Heterozygous	Het	Het	Het
Aldosterone (erect position/decubitus; ng/mL)	0.254/0.257	NA	0.13/0.14
Cortisol (8/16/24 h; ng/mL)	NA	NA	215/261/102
Increased E	NA	NA	NA
Increased NE	NA	1.89 ng/mL	NA
VMA	72.0 µmol/24 h	178.36 µmol/24 h	–
MN	5.1 µmol/24 h	–	–
PTH	41.04 pg/mL	NA	NA
17-OH	13.5 µmol/24 h	–	–
17-KS	30.2 µmol/24 h	–	–
Renin	NA	35.71 µIU/mL; 50.38 µIU/mL (2 h after motivated)	1.08 ng/mL0.75 ng/mL
PRA (erect position/decubitus; ng/mL)	NA	NA	1.08/0.75
Angiotensin II (erect position/decubitus; pg/mL)	NA	NA	39/35
ARR (erect position/decubitus)	NA	NA	12/18
ACTH (8/16/24 h; pg/mL)	NA	NA	10.30/11.15/9.32
Other disease	Thyroid nodule	Atrial flutter	HNPGL; renal cyst
Metastasis	–	–	–
Follow-up (months)	76	5	41
Outcome	NED	NED	NED

‘+’ represented existence of this phenotype, ‘–’ nonexistence; 17-KS, 17-ketosteroid; 17-OH, 17-OH-corticosteroid; ACTH, adrenocorticotropic hormone; ARR, aldosterone renin ratio; E, epinephrine; MN, noradrenaline; NA, not available; NE, norepinephrine; NED, no evidence of disease; PRA, plasma renin activity; PTH, parathyroid hormone; VMA, vanillylmandelic acid.