. 2018 Oct 5;7(12):R304–R315. doi: 10.1530/EC-18-0184
This work is licensed under a Table 4.
Selected prospective randomized controlled trials on the effect of oral/enteral vitamin D in adult critically ill patients.
| Author, Journal, Year | Design | No of patients | Intervention | Outcomes |
|---|---|---|---|---|
| Population | ||||
| Completed trials | ||||
| Amrein K, Critical Care, 2011Graz, Austria (49) | RCTMedical ICU, 25OHD <20 ng/mL | 25 | 1 × 540,000 IU D3, enteral vs placebo | Normalization of vitamin D levels in most patients, no adverse events; no difference in 28-days mortality or length of stay |
| Amrein K, JAMA, 2014Graz, Austria (50) | RCTMixed ICU, 25OHD <20 ng/mL | 475 | 1 × 540,000 IU D3, enteral, then 5 × 90,000 IU D3/month vs placebo | No difference in hospital length of stay, overall no significant mortality benefit, but large and significant mortality benefit in the predefined subgroup with severe vitamin D deficiency (25OHD) <12 |
| Quraishi S, Critical Care Medicine, 2015Boston, USA (51) | RCTICU, sepsis | 30 | 1 × 200,000 IU D3, enteral or 1 × 400,000 IU D3, enteral vs placebo | Rapid correction of vitamin D deficiency, increase in LL-37 compared to the placebo group |
| Han JE, Journal of Clinical and Translational Endocrinology, 2016, Nutrition, 2017Atlanta, USA (52) | RCTICU, mechanically ventilated | 30 | 5 × 50,000 IU D3, enteral or 5 × 100,000 IU D3, enteral vs placebo | Shorter hospital stay, dose dependent increase of vitamin D levels and increased hCAP18 mRNA-expression compared to the placebo group |
| Alizadeh N, International Journal of Clinical Practice, 2016Teheran, Iran (86) | RCTSurgical ICU, stress-induced hyperglycemia | 50 | 600,000 IU D3, IM vs placebo | 25OHD levels increased significantly in the vitamin D group at day 7, fasting plasma adiponectin levels increased significantly in the vitamin D group, but not the placebo group |
| Miroliaee AE, Iranian Journal of Pharmaceutical Research, 2017Teheran, Iran (87) | RCTICU, ventilator associated pneumonia25OHD <30 ng/mL | 46 | 300,000 IU D3, IM vs placebo | PCT levels significantly lower in the vitamin D group compared to placebo group, no significant difference in SOFA score between groups, mortality rate of patients in the vitamin D group was significantly lower than in the placebo group |