Table 3.

Various side effects observed in seven patients who received prolonged low-dose op’DDD monotherapy.

Side effects	Prevalence	Description	Outcome
Adrenal deficiency	2/6	Undetectable serum and urinary cortisol	Normalization after dose decrease
Digestive toxicity	6/6	Nausea, vomiting	Improved after a couple weeks of treatment
Hepatic toxicity	2/6	Isolated cytolysis	/
	1/6	Acute severe hepatitis	Very slow recovery
Neurologic toxicity	4/6	Asthenia	/
	2/6	Difficulties at school	Improvement after dose decrease