Table 1.
Baseline demographic and tumor characteristics of patients in SEER database
| Variables | Fibrosis Score | P Value | ||
|---|---|---|---|---|
| 0–4 | 5–6 | |||
| Age, years | 62.8 ± 11.8 | 61.0 ± 9.2 | < 0.001 | |
| Age | < 60 | 931(40.1) | 4457(47.1) | < 0.001 |
| ≥ 60 | 1390(59.9) | 5005(52.9) | ||
| Sex | Male | 1804(77.7) | 7471(79.0) | 0.194 |
| Female | 517(22.3) | 1991(21.0) | ||
| Ethnicity | White | 1352(58.2) | 6709(70.9) | < 0.001 |
| Asian or Pacific Island | 621(26.7) | 1448(15.3) | ||
| Black | 312(13.5) | 1101(11.6) | ||
| American Indian/Alaska Native | 25(1.1) | 157(1.7) | ||
| Unknown | 11(0.5) | 47(0.5) | ||
| Marital Status | Married | 1298(55.9) | 4818(50.9) | < 0.001 |
| Unmarried | 932(40.2) | 4303(45.5) | ||
| Unknown | 91(3.9) | 341(3.6) | ||
| Year of Diagnosis | 2004–2007 | 670(28.9) | 1833(19.4) | < 0.001 |
| 2008–2011 | 864(37.2) | 3918(41.4) | ||
| 2012–2014 | 787(33.9) | 3711(39.2) | ||
| TNM Stage | I | 944(40.6) | 3520(37.2) | < 0.001 |
| II | 437(18.8) | 2536(26.8) | ||
| III | 524(22.6) | 1840(19.4) | ||
| IV | 280(12.1) | 869(9.2) | ||
| Unknown | 136(5.9) | 697(7.4) | ||
| SEER Stage | Localized | 1365(58.8) | 5366(56.7) | < 0.001 |
| Regional | 621(26.7) | 3015(31.8) | ||
| Distant | 299(12.9) | 910(9.6) | ||
| Unstaged | 36(1.6) | 171(1.8) | ||
| Pathological Grade | Well differentiated | 394(17.0) | 1055(11.2) | < 0.001 |
| Moderately differentiated | 658(28.3) | 1484(15.7) | ||
| Poorly differentiated | 279(12.0) | 524(5.5) | ||
| Undifferentiated | 22(1.0) | 39(0.4) | ||
| Unknown | 968(41.7) | 6360(67.2) | ||
| AFP | Negative | 576(24.8) | 2116(22.4) | < 0.001 |
| Positive | 1324(57.1) | 6234(65.9) | ||
| Borderline | 12(0.5) | 22(0.2) | ||
| Unknown | 409(17.6) | 1090(11.5) | ||
| Tumor Size | < 2 cm | 179(7.7) | 1227(13.0) | < 0.001 |
| ≥ 2 cm | 1918(82.6) | 7386(78.0) | ||
| Unknown | 224(9.7) | 849(9.0) | ||
| Therapy | None | 1190(51.3) | 6536(69.1) | < 0.001 |
| Tumor Destruction | 247(10.6) | 1251(13.2) | ||
| Surgical Resection | 733(31.6) | 639(6.8) | ||
| Liver Transplantation | 137(5.9) | 1022(10.8) | ||
| Unknown | 14(0.6) | 14(0.1) | ||