Table 2.
Univariate Cox model analyses for overall and disease-specific survival
| Variables | Overall Survival | Disease-specific Survival | |||
|---|---|---|---|---|---|
| HR (95%CI) | P Value | HR (95%CI) | P Value | ||
| Age | < 60 | Reference | Reference | ||
| ≥ 60 | 1.12(1.07–1.17) | < 0.001 | 1.13(1.07–1.19) | < 0.001 | |
| Sex | Male | Reference | Reference | ||
| Female | 0.89(0.84–0.95) | < 0.001 | 0.89(0.84–0.95) | < 0.001 | |
| Ethnicity | White | Reference | Reference | ||
| Asian or Pacific Island | 0.73(0.68–0.78) | < 0.001 | 0.73(0.68–0.78) | < 0.001 | |
| Black | 1.16(1.08–1.24) | < 0.001 | 1.14(1.05–1.23) | 0.001 | |
| American Indian/Alaska Native | 1.23(1.03–1.46) | 0.020 | 1.28(1.06–1.54) | 0.012 | |
| Unknown | 0.59(0.39–0.88) | 0.009 | 0.60(0.39–0.94) | 0.024 | |
| Marital Status | Married | Reference | Reference | ||
| Unmarried | 1.34(1.28–1.40) | < 0.001 | 1.31(1.25–1.38) | < 0.001 | |
| Unknown | 1.23(1.09–1.39) | < 0.001 | 1.17(1.02–1.34) | 0.028 | |
| Year of Diagnosis | 2004–2007 | Reference | Reference | ||
| 2008–2011 | 0.92(0.87–0.97) | 0.002 | 0.94(0.88–1.00) | 0.039 | |
| 2012–2014 | 0.85(0.79–0.90) | < 0.001 | 0.85(0.79–0.91) | < 0.001 | |
| TNM Stage | I | Reference | Reference | ||
| II | 1.17(1.10–1.25) | < 0.001 | 1.28(1.19–1.38) | < 0.001 | |
| III | 3.24(3.04–3.45) | < 0.001 | 3.96(3.70–4.25) | < 0.001 | |
| IV | 6.11(5.67–6.60) | < 0.001 | 7.56(6.96–8.22) | < 0.001 | |
| Unknown | 3.86(3.54–4.20) | < 0.001 | 4.39(3.99–4.83) | < 0.001 | |
| SEER Stage | Localized | Reference | Reference | ||
| Regional | 2.25(2.14–2.37) | < 0.001 | 2.56(2.42–2.71) | < 0.001 | |
| Distant | 5.30(4.95–5.69) | < 0.001 | 6.29(5.83–6.78) | < 0.001 | |
| Unstaged | 3.96(3.41–4.61) | < 0.001 | 4.06(3.42–4.81) | < 0.001 | |
| Pathological Grade | Well differentiated | Reference | Reference | ||
| Moderately differentiated | 1.04(0.95–1.14) | 0.399 | 1.09(0.99–1.21) | 0.088 | |
| Poorly differentiated | 1.74(1.56–1.94) | < 0.001 | 2.00(1.78–2.26) | < 0.001 | |
| Undifferentiated | 1.65(1.22–2.23) | 0.001 | 1.81(1.30–2.51) | < 0.001 | |
| Unknown | 1.83(1.70–1.98) | < 0.001 | 1.91(1.75–2.08) | < 0.001 | |
| AFP | Negative | Reference | Reference | ||
| Positive | 1.77(1.66–1.88) | < 0.001 | 1.88(1.76–2.02) | < 0.001 | |
| Borderline | 1.16(0.74–1.83) | 0.513 | 1.45(0.91–2.31) | 0.119 | |
| Unknown | 1.60(1.48–1.74) | < 0.001 | 1.64(1.49–1.80) | < 0.001 | |
| Tumor Size | < 2 cm | Reference | Reference | ||
| ≥ 2 cm | 2.20(2.01–2.40) | < 0.001 | 2.69(2.41–2.99) | < 0.001 | |
| Unknown | 6.98(6.28–7.75) | < 0.001 | 8.94(7.90–10.12) | < 0.001 | |
| Therapy | None | Reference | Reference | ||
| Tumor Destruction | 0.40(0.37–0.43) | < 0.001 | 0.36(0.33–0.40) | < 0.001 | |
| Surgical Resection | 0.29(0.27–0.32) | < 0.001 | 0.28(0.26–0.31) | < 0.001 | |
| Liver Transplantation | 0.12(0.10–0.13) | < 0.001 | 0.07(0.06–0.08) | < 0.001 | |
| Unknown | 1.34(0.91–1.99) | 0.140 | 1.35(0.88–2.07) | 0.174 | |
| Fibrosis Score | 0–4 | Reference | Reference | ||
| 5–6 | 1.16(1.10–1.23) | < 0.001 | 1.11(1.05–1.19) | < 0.001 | |