Table 3.
The correlations between the expressions of BKCa, ERK1/2 and p-ERK1/2 proteins and the clinicopathological parameters in 185 cases with type I endometrial cancer
| Characteristics | BKCa, n (%) | p-value | ERK1/2, n (%) | p-value | p-ERK1/2, n (%) | p-value | |||
|---|---|---|---|---|---|---|---|---|---|
| Low | High | Low | High | Low | High | ||||
| Age | 0.119 | 0.151 | 0.179 | ||||||
| ≤ 60 | 82(44.3) | 40(21.6) | 54(29.2) | 68(36.8) | 65(35.1) | 57(30.8) | |||
| > 60 | 35(18.9) | 28(15.1) | 21(11.4) | 42(22.7) | 27(14.6) | 36(19.5) | |||
| FIGO stage | 0.004 | 0.271 | 0.012 | ||||||
| <II | 80(43.2) | 32(17.3) | 49(26.5) | 63(34.1) | 64(34.6) | 48(25.9) | |||
| ≥II | 37(20.0) | 36(19.5) | 26(14.1) | 47(25.4) | 28(15.1) | 45(24.3) | |||
| Differentiation | 0.733 | 0.345 | 0.623 | ||||||
| Well/moderate | 92(49.7) | 52(28.1) | 61(33.0) | 83(44.9) | 73(39.5) | 71(38.4) | |||
| Poor | 25(13.5) | 16(8.6) | 14(7.6) | 27(14.6) | 19(10.3) | 22(11.9) | |||
| Myometrial invasion | 0.958 | 0.066 | 0.201 | ||||||
| < 1/2 | 95(51.4) | 55(29.7) | 56(30.3) | 94(50.8) | 78(42.2) | 72(38.9) | |||
| ≥1/2 | 22(11.9) | 13(7.0) | 19(10.3) | 16(8.6) | 14(7.6) | 21(11.4) | |||
| Cervical stromal involvement | 0.107 | 0.457 | 0.014 | ||||||
| No | 84(45.4) | 41(22.2) | 53(28.6) | 72(38.9) | 70(37.8) | 55(29.7) | |||
| Yes | 33(17.8) | 27(14.6) | 22(11.9) | 38(20.5) | 22(11.9) | 38(20.5) | |||
| LVSI | 0.104 | 0.183 | 0.046 | ||||||
| No | 112(60.5) | 60(32.4) | 72(38.9) | 100(54.1) | 89(48.1) | 83(44.9) | |||
| Yes | 5(2.7) | 8(4.3) | 3(1.6) | 10(5.4) | 3(1.6) | 10(5.4) | |||
| LNM | 0.011 | 0.407 | 0.018 | ||||||
| No | 114(61.6) | 59(31.9) | 72(38.9) | 101(54.6) | 90(48.6) | 83(44.9) | |||
| Yes | 3(1.6) | 9(4.9) | 3(1.6) | 9(4.9) | 2(1.1) | 10(5.4) | |||
FIGO International Federation of Gynecology and Obstetrics, LVSI lymph vascular space invasion, LNM lymph node metastasis