. 2018 Nov 16;18:1128. doi: 10.1186/s12885-018-5027-9

Table 4.

Univariate and multivariate analysis of the correlations between prognostic value and disease-free and overall survival rates in 185 patients with type I endometrial cancer

Characteristics	Disease-free survival			Overall survival
Characteristics	HR	95% CI	p	HR	95% CI	p
Univariate analysis
Age	2.603	1.321–5.166	0.006	2.777	1.348–5.718	0.006
FIGO stage	2.956	1.454–6.011	0.003	3.420	1.600–7.312	0.002
Differentiation	5.221	2.628–10.375	2.39E⁻⁶	5.516	2.676–11.372	3.72E⁻⁶
Myometrial invasion	4.911	2.477–9.738	5.17E⁻⁶	5.411	2.635–11.112	4.25E⁻⁶
LVSI	6.352	2.940–13.722	2.55E⁻⁶	6.675	3.046–14.627	2.11E⁻⁶
LNM	14.51	6.994–30.103	6.79E⁻¹³	15.02	6.964–32.384	4.84E⁻¹²
Cervical stromal involvement	1.589	0.797–3.170	0.188	1.932	0.942–3.959	0.072
BKCa expression	1.121	0.558–2.253	0.749	1.123	0.541–2.331	0.756
ERK1/2 expression	0.594	0.300–1.175	0.134	0.546	0.267–1.120	0.099
p-ERK1/2 expression	4.149	1.800–9.563	0.001	4.358	1.781–10.664	0.001
Multivariate analysis
Age	1.717	0.842–3.503	0.137	1.912	0.909–4.025	0.088
FIGO stage	1.268	0.538–2.986	0.587	1.607	0.648–3.983	0.306
Differentiation	3.111	1.413–6.851	0.005	3.494	1.520–8.034	0.003
Myometrial invasion	3.096	1.430–6.703	0.004	3.648	1.642–8.106	0.001
LVSI	0.503	0.154–1.647	0.256	0.635	0.196–2.050	0.447
LNM	5.008	1.513–16.573	0.008	3.832	1.145–12.826	0.029
p-ERK1/2 expression	3.912	1.542–9.927	0.004	3.796	1.415–10.180	0.008

FIGO International Federation of Gynecology and Obstetrics, LVSI lymph vascular space invasion, LNM lymph node metastasis, HR hazard ratio, 95% CI, 95% confidence interval