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. 2018 Nov 16;16:313. doi: 10.1186/s12967-018-1690-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Histopathological HE staining in kidney tissues. a Representative photomicrographs of HE-stained kidney sections are presented as indicated by the green arrows. b–e Semi-quantitative analysis of interstitial edema, cytoplasmic vacuolar changes, intratubular cast formation and luminal congestion of the picture ×400. **p < 0.05, *p < 0.01, ***p > 0.05