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. 2018 Nov 17;17:159. doi: 10.1186/s12943-018-0907-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Tob1 stimulates proliferation and Wnt signalling in vivo. a Experimental procedures for the AOM/DSS model. b-d Colon tumour incidence, number and volume in mice. *, P < 0.05. e-f Representative IHC micrographs of PHH3, Ki-67 and cyclin D1 in colon tumours of different mouse models. g ISH analysis of Tob1 expression in the colon tissues of Apc^Min/+ mice