Table 5.
Multivariate logistic model* of factors associated with receipt of adjuvant radiation therapy and chemoradiation therapy among patients aged ≥70 years in subgroups in which adjuvant therapy is warranted
| Patient characteristics | Subgroup with pT3 or pT4 disease or pN2 or pN3 disease (n = 3467) |
Subgroup with ECE present or margin-positive disease (n=1216) |
||
|---|---|---|---|---|
| OR for receipt of radiation therapy (95% CI) | P value | OR for receipt of chemoradiation therapy (95% CI) | P value | |
| Age | 0.95 (0.93–0.96) | <.0001 | 0.94 (0.92–0.96) | <.0001 |
| Sex | .15 | .93 | ||
| Male | Reference | Reference | ||
| Female | 0.90 (0.78–1.04) | 0.99 (0.78–1.26) | ||
| Race | .85 | .71 | ||
| White | Reference | Reference | ||
| Black | 1.05 (0.76–1.45) | 0.93 (0.51–1.70) | ||
| Other | 0.92 (0.65–1.30) | 0.78 (0.42–1.45) | ||
| Year of diagnosis | .05 | .2 | ||
| 2004–2006 | Reference | Reference | ||
| 2007–2009 | 0.71 (0.60–0.85) | 1.14 (0.81–1.61) | ||
| 2010–2012 | 1.02 (0.85–1.22) | 1.31 (0.97–1.79) | ||
| Charlson-Deyo comorbidity score | .0002 | .56 | ||
| 0 | Reference | Reference | ||
| 1 | 0.71 (0.60–0.85) | 0.85 (0.64–1.14) | ||
| ≥2 | 0.73 (0.54–0.98) | 0.96 (0.60–1.53) | ||
| Location | .0008 | .09 | ||
| Northeast | Reference | Reference | ||
| South | 0.67 (0.55–0.83) | 0.69 (0.48–0.98) | ||
| Central | 0.87 (0.70–1.08) | 0.82 (0.57–1.18) | ||
| West | 0.75 (0.59–0.96) | 0.63 (0.41–0.95) | ||
| Facility type | <.0001 | .06 | ||
| Community cancer program | Reference | Reference | ||
| Comprehensive community cancer program | 0.70 (0.47–1.04) | 0.63 (0.34–1.16) | ||
| Academic or research program | 0.45 (0.30–0.66) | 0.50 (0.27–0.92) | ||
| Integrated network cancer program | 0.40 (0.25–0.64) | 0.43 (0.20–0.91) | ||
| Distance from reporting facility | <.0001 | .0008 | ||
| ≤50 miles | Reference | Reference | ||
| >50 miles | 0.66 (0.55–0.81) | 0.56 (0.40–0.79) | ||
| Residence | .81 | .98 | ||
| Metropolitan | Reference | Reference | ||
| Urban | 0.99 (0.80–1.23) | 0.98 (0.68–1.42) | ||
| Rural | 1.18 (0.70–2.01) | 1.08 (0.45–2.60) | ||
| Income | .16 | .76 | ||
| <$35,000 | Reference | Reference | ||
| ≥$35,000 | 0.89 (0.75–1.05) | 1.05 (0.79–1.39) | ||
| Site | .23 | .27 | ||
| Tongue | Reference | Reference | ||
| Gum | 0.83 (0.68–1.01) | 1.37 (0.98–1.92) | ||
| Floor of mouth | 0.94 (0.75–1.05) | 1.03 (0.72–1.47) | ||
| Palate | 1.03 (0.72–1.48) | 1.62 (0.86–3.05) | ||
| Other | 1.02 (0.83–1.26) | 1.15 (0.82–1.60) | ||
Abbreviations: CI = confidence interval; ECE = extracapsular extension; OR = odds ratio.
*
Adjusted for sex; race; year of diagnosis; comorbidity score; region of country; facility; oral cavity site; distance from facility; income; and urban, metropolitan, or rural residence.