Table 1.

Gene	Highly expressing tissues	Clinical significance/Genetic disorders
LOX	Placenta, adipose tissue, breast, smooth muscle, heart muscle, skin, lung, bladder, endometrium	aortic aneurysm, multiple types of cancer [5, 6, 18–20]
LOXL1	Placenta, adipose tissue, seminal vesicle, smooth muscle, heart muscle, bladder, ocular tissue	pseudoexfoliation syndrome [21]
LOXL2	Placenta, adipose tissue, smooth muscle, bladder, appendix, endometrium	multiple types of cancer [22–24]
LOXL3	Placenta, smooth muscle, bladder, spleen, bone marrow, endometrium	Stickler syndrome [25]
LOXL4	Placenta, breast, seminal vesicle, smooth muscle, bone marrow, endometrium	multiple types of cancer [26]

ADAMTSL2	Lung, musculoskeletal tissues, brain, dermis, myocardium	Geleophysic dysplasia [16]
ADAMTSL4	Ocular tissue, vascular smooth muscle	Ectopia lentis [27], ectopia lentis et pupillae [28]
ADAMTS10	Ocular tissue, lung, vascular smooth muscle, musculoskeletal tissues, connective tissue stroma of most organs	Weill-Marchesani syndrome [29]