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. Author manuscript; available in PMC: 2018 Nov 18.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2017 Sep 27;14(12):711–726. doi: 10.1038/nrgastro.2017.126

Figure 3 |. Histopathological findings in GVHD of the gastrointestinal tract.

Figure 3 |

Haematoxylin and eosin (H&E) staining of acute graft-versus-host disease (GVHD) of the gastrointestinal tract, illustrating common histopathological findings. a | Oxyntic mucosa of the stomach showing apoptotic epithelial cells in multiple crypts (black arrows, ×200). The nuclei of the apoptotic cells shrink in size, the chromatin condenses and nuclear fragmentation occurs. b | Colonic mucosa depicting multiple withered and necrotic crypts (arrow heads, ×200). c | Colonic biopsy showing areas of extensive crypt loss (black arrow). The remaining two crypts (white arrows) show reactive epithelial changes (×100).