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. Author manuscript; available in PMC: 2018 Nov 18.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2017 Sep 27;14(12):711–726. doi: 10.1038/nrgastro.2017.126
Stage Target organ
Skin (active erythema only) Liver (serum total bilirubin) Upper gastrointestinal Lower gastrointestinal (stool output)
0 No active (erythematous) rash <2 mg/dL (<34.21 μmol/L) No or intermittent nausea, vomiting or anorexia

  • Adult: <500 mL per day

  • Child: <10 mL/kg per day
1 Maculopapular rash, <25% BSA 2–3 mg/dL (34.21–51.31 μmol/L) Persistent nausea, vomiting or anorexia

  • Adult: 500–999 mL per day

  • Child: 10–19.9 mL/kg per day
2 Maculopapular rash, 25–50% BSA 3.1–6 mg/dL (53.02–102.62 μmol/L) –

  • Adult: 1,000–1,500 mL per day

  • Child: 20–30 mL/kg per day
3 Maculopapular rash, >50% BSA 6.1–15 mg/dL (104.33–256.56 μmol/L) –

  • Adult: >1,500 mL per day

  • Child: >30 mL/kg per day
4 Generalized erythroderma (>50% BSA), plus bullous formation and desquamation (>5% BSA) >15 mg/dL (>256.56 μmol/L) – Severe abdominal pain with or without ileus or grossly bloody stool (regardless of volume)