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. Author manuscript; available in PMC: 2018 Nov 18.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2017 Sep 27;14(12):711–726. doi: 10.1038/nrgastro.2017.126

Table 2 |.

Grading histological severity in gastrointestinal acute GVHD

Grade Histological classification
1 Isolated apoptotic epithelial cells without crypt loss
2 Crypt necrosis, withering and individual crypt loss
3 Contiguous areas of multiple crypt loss
4 Extensive crypt dropout with denudation of the epithelium

Data from REF. 99 and REF. 104.