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. Author manuscript; available in PMC: 2018 Nov 18.
Published in final edited form as: J Bone Miner Res. 2018 Jan 26;33(4):691–703. doi: 10.1002/jbmr.3342

Figure 7. The deficiency of C/ebpα in OCs blocks ovariectomy (OVX)-induced bone loss in osteoporosis mouse model.

Figure 7.

C/ebpα’s roles in OVX-induced bone loss analysis were examined in 8-week-old C/ebpαf/f (f/f) and C/ebpαf/fLysM-Cre (f/f/Δ) mice at 4 weeks after sham surgery and OVX (n=15). (A) Mouse photographic images and (B) assessment of uterine size to confirm the effects of OVX. (C) Representative images of radiographic analysis of mouse femurs. (D) High power image of the epiphysis regions from C data. No significant changes were found between sham- and OVX-C/ebpαf/fLysM-Cre. Compared to OVX-C/ebpαf/f which displayed significant bone loss, C/ebpα-deficient mice retained normal bone mineral density similar to that of sham-C/ebpαf/f control. (E) μCT analysis of C/ebpαf/f and C/ebpαf/fLysM-Cre mice femurs from C-D (n=4). (F) Quantification of E revealed that femurs from OVX-C/ebpαF/FLysM-Cre mice retained significantly higher ratios of bone volume/tissue volume and increased trabecular numbers compared to OVX-C/ebpαf/f mice at 4 weeks post-operation. Labels: (BV) bone volume, (TV) total bone volume. (Conn.D) connectivity density, (Tb.N) trabecular number, (Tb.Sp) trabecular separation, (Tb.Th) trabecular thickness. Bars show means ± SD. of triplicate independent samples. *p<0.05, **p<0.01, ***p<0.005. N.S, not significant.