Skip to main content
. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Bone. 2018 May 18;118:2–7. doi: 10.1016/j.bone.2018.05.019

Figure 1.

Figure 1

Differentiation of BMSCs to osteogenic and adipogenic lineages. Bone marrow mesenchymal stem cells (BMSCs) are signaled to differentiate to osteoblasts by transcription factors such Runx2 and Osx1 or to adipocytes by Pparγ and c/EBPα. BMSC-derived osteoblasts can further differentiate into mature osteocytes or may become lipid-storing cell types. This diagram illustrates a potential lineage-switching mechanism between osteoblasts and adipocytes as well as a reduction of lipid storage within osteogenic cells by histone deacetylase 3 (Hdac3) and its associated cofactors.