Table 1. List of the Most Relevant Mutations in Hepatocellular Carcinoma.

De-regulated pathway	Gene	Frequency (%)		Etiology enrichment
Telomere maintenanc	TERT	70	Gain of function	Alcohol
Cell cycle control	TP53	30	Loss of function	HBV
	RB1	8	Loss of function
	CDKN2A	8	Loss of function	Alcohol
	CCND1	7	Gain of function
	CCNE1	5	Gain of function
Wnt signaling	CTNNB1	30	Gain of function	Alcohol
	AXIN1	11	Loss of function
	ZNRF3	3	Loss of function
	AXIN2	1
	APC	1	Loss of function
Chromatin remodeling	ARID1A	13	Loss of function	Alcohol
	MLL4	10
	ARID2	7
	KMT2D	6
	KMT2B	3
	KMT2C	2
PI3K/mTOR signaling	TSC2	5	Loss of function
	TSC1	3	Loss of function
	DAPK1	3	Loss of function
	PI3CA	3	Gain of function
	mTOR	2	Gain of function
RAS/MAPK signaling	RPS6KA3	7	Loss of function
	FGF19	4	Gain of function
	NTRK3	3
	EPHA4	3
JAK/STAT signaling	IL6ST	3	Gain of function
	JAK1	1
Oxidative stress	NFE2L2	6	Gain of function
	KEAP1	4	Loss of function