Table 2.
Known and novel autoantigen substrates of MMP-9 in achalasia
| Reduced levels | Auto-antibodies | MMP-9 substrate (known reference) | MMP-9 substrate (new) | |
|---|---|---|---|---|
| VIP | + | ✓ | ||
| nNOS | + | |||
| S-100 | + | +A8/A9(30) | ||
| Substance P | + | +(31) | ||
| PGP 9.5 | + | |||
| Amphiphysin | + | |||
| CV2 | + | |||
| PNMA2 | + | ✓ | ||
| Ri | + | ✓ | ||
| Yo | + | |||
| Hu | + | |||
| Recoverin | + | Not a substrate | ||
| SOX-1 | + | |||
| Titin | + | |||
| GAD65 | + | ✓ |
Autoantigens in achalasia (column 1) are discriminated on the basis of disappearance (column 2) or presence of detectable autoantibodies (column 3) in patients with achalasia. Columns 4 and 5, respectively, document whether these autoantigens were already known or discovered in the present study as substrates of MMP-9