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Anthracyclines such as doxorubicin family induce ROS production, DNA damage, apoptosis, and senescence leading to phenotypical and functional changes in the key cardiac and progenitor cells. Indeed, somatic cell derived iPSCs can differentiate into cardiomyocytes. These iPSC-CMs can be used to study new mechanisms of anthracycline-mediated cardiotoxicity and to detect genetic variance to cardiotoxicity in the cancer patients.
