Table 3.
Antagonism of PAS and pterin-PAS by methionine.
| PAS MIC90a | Pterin-PAS MIC90 | |||
|---|---|---|---|---|
| Strain | –Met | +Metb | –Met | +Met |
| M. bovis BCG | 1 (6.53) | >250 (1630) | 5 (15.1) | >20 (61.5) |
| M. tuberculosis H37Ra | 0.6 (3.92) | >250 (1630) | ND | ND |
| M. tuberculosis H37Ra ΔpabB | 0.15 (0.98) | 0.3 (1.96) | ND | ND |
a
MIC90 is defined as the minimum concentration of drug required to restrict at least 90% of growth relative to growth seen in the no-drug control cultures. MIC90 are shown in μg/ml (μM).
ND, not determined; Met, methionine; PAS, para-aminosalicylic acid.
b
Methionine was supplemented at 10 μg/ml.