Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic overview of feedback regulation of the MAPK pathway. Several feedback mechanisms are in place to control the MAPK pathway. ERK1/2 phosphorylates many upstream components and induces transcription of regulators such as Sproutys and DUSPs, which help to balance correct signaling strength in a given cell.
