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. 2018 Nov 12;9:2494. doi: 10.3389/fimmu.2018.02494

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Copyright © 2018 Holder, Lajoie and Grant.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of HCMVsn and IFN-α2 on ADCC of NK cells from HIV-infected individuals. (A) ADCC within the HIV-infected group was measured in ⁵¹Cr release assays over 5 h at E:T 30:1 in the presence of a 1:5 dilution of HCMVsn or 20 pg/mL recombinant human IFN-α2 as previously described and compared to untreated conditions (n = 21). (B) Baseline ADCC levels were compared between the three groups of HIV-infected individuals distinguished by HCMV serostatus and fraction of NK cells expressing NKG2C. Error bars represent median with IQR, performed in duplicate with conditions compared using Wilcoxon signed-rank test.