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. 2018 Nov 12;9:2582. doi: 10.3389/fimmu.2018.02582

Table 2.

Summary of the studies in human tumors using scRNAseq.

Cancer type Tumor cell types scRNAseq method Cell number References
Glioblastoma Cancer epithelial cells Smart-seq 430 (150)
Oligodendrogliomas Cancer epithelial cells Smart-seq2 4,347 (151)
Hepatocellular cancer Cancer epithelial cells scTrio-seq 25 (152)
Renal carcinoma PDX Fluidigm C1/SMARTer 116 (153)
Lung adenocarcinoma PDX Smart-seq 34 (154)
Chronic myeloid leukemia LinCD34+CD38 cells BCR-ABL-targeted Smart-seq2 2,000 (155)
Breast cancer (TNBC) Cancer epithelial cells Nanogrid single-nucleus RNA seq 7,278 (148, 156)
Hepatocellular cancer CD8+ and CD4+ T cells Smart-seq2 5,063 (113)
Gliomas Inter (CD11b+) and Intra tumor TAMs (in silico) 10X Genomics 4,039 (157)
Gliomas Inter (CD11b+) and Intra tumor TAMs (in silico) Fluidigm C1/SMARTer 466 (157)
Non-small-cell lung cancer CD3+ TILs Smart-seq2 12,346 (115)
Breast cancer (TNBC) CD3+ TILs 10X Genomics Chromium 6,311 (117)
Breast cancer (ER+PR+, Her2+, TNBC) Immune cells (CD45+) inDrop 47,016 (114)
Breast cancer (ER+PR+, Her2+, TNBC) CD3+ TILs 10X Genomics Chromium (scRNA-seq and paired V(D)J sequencing) 27,000 (114)
Melanoma All cell types in tumor Smart-seq2 4,645 (112)
Head and neck cancer All cell types in tumor Smart-seq2 5,902 (158)
Breast cancer(ER+PR+, Her2+, TNBC) All cell types in tumor Fluidigm C1/SMARTer 515 (111)
Colorectal cancer All cell types in tumor Fluidigm C1/SMARTer 590 (159)
Non-small-cell lung cancer All cell types in tumor 10X Genomics Chromium 92,948 (116)