Table 4.

Effects of scopolamine on neurons depolarized by muscarine.

Depolarized type B (n = 11)	I: Control	II: Muscarine alone (10 μM)	III: Muscarine (10 μM) +Scopolamine (10 μM)	p-value
				I vs. II	II vs. III	I vs. III
Vm (mV)	−48.37 ± 3.97	−45.08 ± 4.72	−47.89 ± 3.68	0.001	0.001	0.52
F (Hz)	13.50 ± 12.54	23.04 ± 16.71	16.48 ± 14.31	0.001	0.003	0.32
CV	24.18 ± 21.91	19.67 ± 33.44	22.31 ± 21.42	0.24	0.102	0.638
AHP (mV)	24.68 ± 4.31	25.89 ± 4.61	26.45 ± 4.87	0.042	0.175	0.0019
Width (ms)	0.81 ± 0.50	0.86 ± 0.51	0.87 ± 0.59	0.0047	0.848	0.186
Concavity (mV)	−0.91 ± 1.87	−0.39 ± 0.76	−1.36 ± 2.10	0.188	0.125	0.813
Convexity (mV)	0.73 ± 0.70	0.90 ± 0.66	0.78 ± 0.53	0.24	0.465	0.7
AHPR (V/s)	0.02 ± 0.03	0.03 ± 0.07	0.03 ± 0.08	0.625	0.625	0.625
dAHP (V/s)	6.36 ± 4.54	5.26 ± 4.13	5.51 ± 4.28	0.0014	0.432	0.105
Resistance Hyperpol. (MΩ)	362 ± 203	470 ± 277	396 ± 232	0.002	0.002	0.375
Resistance Depol. (MΩ)	101 ± 49	128 ± 54	106 ± 49	0.002	0.002	0.492

Vm, membrane potential, F, spontaneous discharge frequency, CV, coefficient of variation of the spontaneous discharge, AHP, After HyperPolarization, Width, spike width at threshold, Concavity and convexity: quantification of the shape of the interspike interval, AHPR, quantification of the AHP rectification, dAHP, quantification of the double AHP, Resistance hyperpol: slope of the IV curve in response to hyperpolarizing steps, Resistance depol: slope of the IV curve in response to depolarizing steps. For more details on how these parameters are calculated see (31, 36, 37). Statistically significant differences are highlighted in red.