Table 1.
Characteristics and cholesterol profiles in 3,467 Chinese adults with different diagnoses of cognition at baseline.
| Total (N = 3,467) | Normal (N = 2,778) | MCI (N = 603) | Dementia (N = 86) | P value# | |
|---|---|---|---|---|---|
| Sex, female, n (%) | 1,893 (54.6) | 1,511 (54.4) | 331 (54.9) | 51 (59.3) | 0.4772 |
| Age, year, mean (SD) | 69.4 (8.0) | 68.5 (7.5) | 72.4 (8.7) | 78.2 (7.7) | < 0.0001** |
| BMI, mean (SD) | 24.3 (3.4) | 24.3 (3.4) | 24.4 (3.6) | 24.0 (3.9) | 0.5424 |
| Education, year, mean (SD) | 11.7 (4.0) | 12.2 (3.7) | 10.1 (4.6) | 8.0 (6.0) | < 0.0001** |
| Smoking, n (%) | 377 (10.9) | 297 (10.7) | 75 (12.5) | 5 (5.8) | 0.9500 |
| Stroke, n (%) | 377 (10.9) | 275 (9.9) | 87 (14.5) | 15 (17.7) | 0.0001** |
| Hypertension, n (%) | 1,769 (51.2) | 1,370 (49.4) | 339 (56.6) | 60 (70.6) | < 0.0001** |
| Diabetes, n (%) | 460 (13.3) | 344 (12.4) | 104 (17.4) | 12 (14.1) | 0.0064** |
| APOE-ε4 (+), n (%) | 589 (17.7) | 456 (17.0) | 114 (20.0) | 19 (22.6) | 0.0349* |
| Depression, n (%) | 599 (17.3) | 439 (15.9) | 135 (22.5) | 25 (29.1) | < 0.0001** |
| ADL, mean (SD) | 20.7 (4.2) | 20.3 (2.3) | 21.1 (4.7) | 32.0 (15.8) | < 0.0001** |
| MMSE, mean (SD) | 28.0 (2.7) | 28.6 (1.6) | 26.8 (2.7) | 16.8 (5.5) | < 0.0001** |
| TC, mmol/L, mean (SD) | 5.4 (1.0) | 5.4 (1.1) | 5.3 (1.0) | 5.2 (1.0) | 0.1153 |
| LDL-C, mmol/L, mean (SD) | 3.3 (0.9) | 3.3 (0.9) | 3.3 (0.9) | 3.2 (1.0) | 0.0921 |
| HDL-C, mmol/L, mean (SD) | 1.3 (0.3) | 1.3 (0.3) | 1.3 (0.4) | 1.4 (0.3) | 0.6733 |
| TC, category | 0.0290* | ||||
| Low | 1,148 (33.1) | 902 (32.5) | 211 (35.0) | 35 (40.7) | |
| Moderate | 1,169 (33.7) | 935 (33.7) | 206 (34.2) | 28 (32.6) | |
| High | 1,150 (33.2) | 941 (33.9) | 186 (30.9) | 23 (26.7) | |
| LDL-C, category | 0.0221* | ||||
| low | 1,073 (31.0) | 843 (30.4) | 193 (32.0) | 37 (43.0) | |
| Moderate | 1,307 (37.7) | 1,047 (37.7) | 231 (38.3) | 29 (33.7) | |
| High | 1,083 (31.3) | 884 (31.9) | 179 (29.7) | 20 (23.3) | |
| HDL-C, category | 0.5419 | ||||
| Low | 1,148 (33.2) | 918 (33.1) | 203 (33.7) | 27 (31.4) | |
| Moderate | 1,175 (33.9) | 951 (34.3) | 199 (33.0) | 25 (29.1) | |
| High | 1,140 (32.9) | 905 (32.6) | 201 (33.3) | 34 (39.5) |
#
Comparison among groups with different diagnoses of cognition.
*
P-value < 0.05,
**
P-value < 0.01.
MCI, mild cognition impairment; BMI, body mass index; MMSE, Mini-Mental State Examination; APOE-ε4 (+), ApoE-ε4 allele positive; ADL, Activities of Daily Living; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.
TC: low, < 4.87 mmol/L; moderate, 4.87–5.72 mmol/L; high, >5.72 mmol/L.
LDL-C: low, < 2.9 mmol/L; moderate, 2.9–3.7 mmol/L; high, >3.7 mmol/L.
HDL-C: low, < 1.17 mmol/L; moderate, 1.17–1.45 mmol/L; high, >1.45 mmol/L.