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. 2018 Nov 12;12:402. doi: 10.3389/fncel.2018.00402

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Copyright © 2018 Hatami, Conrad, Naghsh, Alvarez-Bolado and Skutella.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dentate gyrus (DG) development in the mouse from E10 to postnatal stage. (A) The migration and differentiation of granule cells is controlled by the CH, a glial scaffold formed by radial glial cells (RGCs) and CR lining the HF. At E10–E12.5 DG precursor cells (small dark blue) start to develop in the DNE, adjacent to CH (light blue). (B) By E14–E15.5 the first migration of DG precursors is initiated. (C) By E17.5 DG precursors and granule cells have begun to mix and form the 2ndM and 3ndM. (D) By P0 condensing of granule cell layers (GCLs) in subgranular zone. HNE, Hippocampus Neuroepithelium; DNE, Dentate Neuroepithelium; CH, Cortical Hem; ChP, Choroid Plexus; CP, Coroid Plaque; 1stM, First Matrix; MS, Migratory Stream; CR, Cajal Retzius; 2ndM, Second Matrix; 3ndM, Third Matrix; HF, hippocampal fissure; F, Fimbria.