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. 2018 Nov 16;12(2):282–291. doi: 10.1016/j.tranon.2018.10.013

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Caspases are significantly downregulated in CRC. (A) In the TCGA CRC series, miR-224 resulted significantly upregulated in CRCs in comparison to normal samples (P = .001688), whereas both caspases were significantly downregulated (caspase-3, P = 6.67e-08; caspase-7, P < 2.2e-16). (B) Caspase-3 expression was significantly downregulated in CRC in comparison to normal mucosa in 4 out of 6 Oncomine deposited studies (a total of 269 CRCs and 107 normal samples analyzed; P = .010). (C) Caspase-7 was significantly downregulated in 7 out of 8 studies (a total of 415 CRCs and 186 normal samples analyzed; P = 1.02e-5).