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. 2018 Aug 24;27(23):4135–4144. doi: 10.1093/hmg/ddy305

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Composition of human TIM22 complex and mechanism of action.

The TIM22 complex is comprised of the central twin-pore forming unit TIM22, in addition to TIM10B and the metazoan specific subunits, TIM29 and AGK. A soluble hexameric ring, made up of TIM9 and TIM10A and present in the IMS, guides precursors (carrier proteins or TIM22, TIM23, TIM17A/B) from the TOM complex to the TIM22 complex. Upon docking to the TIM22 complex, the precursor is released into the TIM22 channel and its insertion into the membrane is driven by the mitochondrial membrane potential Δψ.