Figure 6.

Schematic summary of the proposed mechanistic effect of the PLX‐RAD secretome on mitigation of ARS by PLX‐RAD cells. IM injected PLX‐RAD cells in irradiated mice seem to respond to the systemic radiation‐induced stress. This triggers a fast secretion of high levels of the relevant proteins by the PLX‐RAD cells. The induced PLX‐RAD derived human secretome is accompanied by enhanced secretion of murine counterparts. The human cytokine peak profiles seem to precede the recovery of damaged haematopoiesis by a short interval, and they occur just prior to the anticipated radiation‐related mortality of the untreated control group. The proteins known to be directly associated with haematopoiesis regeneration are highlighted in red, but other proteins could also be indirectly involved in processes such as cell migration from the haematopoietic niches into the circulation.