Table 2.
Texture and hippocampal volume in distinguishing normal controls (NC) from patients with Alzheimer's disease (AD)
| Variable | Texture value |
ROC analysis |
95% CI | Sens (%) | Spec (%) | P value | |
|---|---|---|---|---|---|---|---|
| NC (n = 225) | AD (n = 183) | AUC | |||||
| Autoc (+) | 42.6 ± 4.5 | 35.1 ± 6.2 | 0.837 | 0.797–0.871 | 75.4 | 78.7 | <.0001 |
| Autoc (−) | 42.0 ± 3.1 | 45.8 ± 3.3 | 0.809 | 0.767–0.846 | 66.1 | 85.3 | <.0001 |
| Corrm (+) | 69.7 ± 16.4 | 45.1 ± 19.6 | 0.828 | 0.788–0.864 | 74.9 | 76.9 | <.0001 |
| Corrm (−) | 77.7 ± 12.0 | 88.8 ± 14.3 | 0.722 | 0.676–0.765 | 74.3 | 61.3 | <.0001 |
| Dissi (+) | 32.6 ± 9.1 | 18.7 ± 10.8 | 0.828 | 0.788–0.864 | 77.1 | 76.9 | <.0001 |
| Dissi (−) | 27.6 ± 4.0 | 33.6 ± 4.9 | 0.825 | 0.784–0.869 | 77.6 | 71.6 | <.0001 |
| Energ (+) | 45.6 ± 8.3 | 32.1 ± 9.0 | 0.866 | 0.830–0.898 | 81.4 | 77.8 | <.0001 |
| Homom (+) | 124.2 ± 12.0 | 99.5 ± 19.0 | 0.866 | 0.829–0.897 | 76.0 | 84.9 | <.0001 |
| Savgh (+) | 133.1 ± 13.1 | 108.9 ± 19.4 | 0.850 | 0.812–0.883 | 78.1 | 79.1 | <.0001 |
| Savgh (−) | 146.2 ± 5.7 | 153.2 ± 5.8 | 0.815 | 0.774–0.852 | 66.1 | 86.7 | <.0001 |
| Senth (+) | 121.1 ± 26.2 | 76.6 ± 34.5 | 0.840 | 0.800–0.874 | 74.3 | 80.9 | <.0001 |
| Senth (−) | 120.0 ± 12.8 | 138.0 ± 13.8 | 0.825 | 0.785–0.861 | 77.6 | 75.1 | <.0001 |
| Sosvh (+) | 83.8 ± 9.9 | 67.6 ± 13.4 | 0.836 | 0.796–0.870 | 76.0 | 78.2 | <.0001 |
| Sosvh (−) | 84.3 ± 6.3 | 92.5 ± 6.8 | 0.818 | 0.777–0.854 | 63.4 | 90.2 | <.0001 |
| Texture (all features) | 0.928 | 0.898–0.951 | 88.0 | 84.9 | <.0001 | ||
| HOC | 0.843 | 0.804–0.877 | 77.6 | 79.6 | <.0001 | ||
| Texture (all features) + HOC | 0.930 | 0.901–0.953 | 83.1 | 92.0 | <.0001 | ||
Abbreviations: ROC, receiver operating characteristic; AUC, area under curve, CI, confidence interval; Sens, sensitivity; Spec, specificity; HOC, hippocampal occupancy.