Table 3.
Texture, hippocampal occupancy, clinical variables, and the resulting area under curve in distinguishing mild cognitive impairment nonconverters (MCI-NC) from MCI converters (MCI-C)
| Variable | Texture value |
ROC analysis |
95% CI | Sens (%) | Spec (%) | P value | |
|---|---|---|---|---|---|---|---|
| Non-converters | Converters | AUC | |||||
| Autoc (+) | 41.8 ± 5.2 | 36.3 ± 6.0 | 0.753 | 0.688–0.810 | 73.5 | 69.8 | <.0001 |
| Autoc (−) | 42.1 ± 3.5 | 44.8 ± 3.1 | 0.709 | 0.641–0.770 | 82.7 | 49.1 | <.0001 |
| Corrm | 53.4 ± 18.2 | 34.9 ± 17.4 | 0.774 | 0.710–0.829 | 83.7 | 62.3 | <.0001 |
| Homom | 108.8 ± 16.6 | 88.0 ± 18.5 | 0.794 | 0.732–0.848 | 64.3 | 80.2 | <.0001 |
| Senth | 94.5 ± 37.8 | 57.6 ± 35.2 | 0.762 | 0.697–0.819 | 81.6 | 63.2 | <.0001 |
| HOC | 0.655 | 0.585–0.720 | 64.3 | 64.2 | <.0001 | ||
| Texture | 0.825 | 0.766–0.875 | 71.4 | 79.3 | <.0001 | ||
| Texture + HOC | 0.881 | 0.828–0.922 | 87.8 | 75.5 | <.0001 | ||
| Texture + HOC + APOE-ε4 | 0.895 | 0.845–0.933 | 90.8 | 73.6 | <.0001 | ||
| Texture + HOC + APOE-ε4 + MMSE + Sex | 0.905 | 0.856–0.941 | 86.7 | 83.0 | >.0001 | ||
Abbreviations: ROC, receiver operating characteristic; AUC, area under curve, CI, confidence interval; Sens, sensitivity; Spec, specificity; MMSE, Mini-Mental Status Examination; HOC, hippocampal occupancy.