Table 3.
Summary of validation results: Positive predictive values, overall and by patient characteristics.
| Characteristic | Number of patients identified (denominator)a | Number of patients confirmed as ADAPTABLE-eligible (numerator) | Estimated PPV | Exact 95% confidence interval |
|---|---|---|---|---|
| All patients - abstractor | 185 | 158 | 0.854 | 0.795, 0.902 |
| All patients, after clinical expert review (main study result) | 185 | 168 | 0.908 | 0.857, 0.946 |
| Sensitivity analysis: Cases of CAD recorded on medical record without AMI, PCI, or CABG counted in the numerator | 185 | 172 | 0.930 | 0.883, 0.962 |
| By qualifying events/cardiac history as measured in claims | ||||
| Patients in AMI stratum (Stratum 1) | 107 | 97 | 0.907 | 0.835, 0.954 |
| Patients in PCI/CABG stratum (Stratum 2) | 78 | 71 | 0.910 | 0.824, 0.963 |
| By patient demographic characteristics | ||||
| Patients aged < 65 years | 35 | 34 | 0.971 | 0.851, 0.999 |
| Patients aged ≥ 65 years | 150 | 134 | 0.893 | 0.833, 0.938 |
| Female patients | 70 | 62 | 0.886 | 0.787, 0.949 |
| Male patients | 115 | 106 | 0.922 | 0.857, 0.964 |
PPV = positive predictive value; AMI = acute myocardial infarction; PCI = percutaneous coronary intervention; CABG = coronary artery bypass graft; CAD = coronary artery disease.
a
Excluding patients whose records were unobtainable.