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Characteristic immunohistochemical staining of Secreted Frizzled Related Protein 1 (SFRP1) expression in astrocytoma. (A) Negative control; (B) astrocytic brain tumor grade II showing strong cytoplasmic staining; (C) astrocytic brain tumor grade IV (glioblastoma) showing strong cytoplasmic staining (both B and C with unmethylated promoters of SFRP1 gene); (D) astrocytic brain tumor grade IV (glioblastoma) with methylated promoter of SFRP1 gene showing lack of expression.
