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. 2018 Oct 26;5(4):MMT10. doi: 10.2217/mmt-2018-0004

Table 2. . Summary of reported immune checkpoint inhibitors experience in patients with solid organ transplants.

Patient Study Transplant Cancer ICI agent Rejection (Y/N) Immunosuppression prior to ICI Immunosuppression during ICI treatment Outcome
1 Lipson et al. Kidney MM Ipilimumab N Prednisone/tacrolimus Prednisone Response

2 Lipson et al. Kidney MM Ipilimumab N Prednisone/tacrolimus/mycophenolate Prednisone Response

3 Ranganath et al. Liver MM Ipilimumab N Tacrolimus Tacrolimus POD

4 Morales et al. Liver MM Ipilimumab N Rapamycin/mycophenolate Rapamycin Response

5 Jose et al. Kidney Metastatic Choroidal Melanoma Ipilimumab Y Tacrolimus Prednisolone Not Reported

6 Herz et al. Kidney MM Ipilimumab N Prednisone/tacrolimus Prednisone/tacrolimus POD

Nivolumab (after ipilimumab)                

7 Spain et al. Kidney MM Ipilimumab N Prednisone/tacrolimus Prednisone POD

Nivolumab (after ipilimumab) Y Prednisone Response          

8 Alhamad et al. Kidney Metastatic SCC of skin Ipilimumab N Cyclosporine/prednisone Prednisone POD

Nivolumab (after ipilimumab) Y Prednisone Not reported          

9 Qin et al. Heart MM Ipilimumab N Tacrolimus Tacrolimus POD

Pembrolizumab (after ipilimumab)                

10 Grant et al. Heart MM Pembrolizumab N Tacrolimus/mycophenolate Tacrolimus/mycophenolate POD

11 Ong et al. Kidney MM Nivolumab Y Prednisone/tacrolimus/mycophenolate Prednisone Response

12 Lipson et al. Kidney Metastatic SCC of skin Pembrolizumab Y Cyclosporine/prednisone Prednisone Response

13 Owonikoko et al. Heart Metastatic SCC of skin Nivolumab Y Tacrolimus/sirolimus Prednisone/tacrolimus Not reported

14 Barnett et al. Kidney Metastatic Adenocarcinoma of the Duodenum Nivolumab N Prednisone/tacrolimus/mycophenolate Prednsione/sirolimus Response

15 Boils et al. Kidney Stage IV NSCLC Nivolumab Y Cyclosporine/prednisone Reduced dose cyclosporine/prednisone Not reported

16 Kittai et al. [68] Kidney Metastatic SCC of skin Nivolumab N Prednisone/tacrolimus/mycophenolate Prednisone/sirolimus Response

17 Kittai et al. Orthotopic Heart Transplant Stage IV NSCLC Nivolumab N Prednisone/cyclosporine/mycophenolate Reduced dose cyclosporine/reduced dose mycophenolate Response

ICI: Immune checkpoint inhibitor; MM: Metastatic melanoma; N: No; NSCLC: Non-small-cell lung cancer; POD: Progression of disease; SCC: Squamous cell carcinoma; Y: Yes.