Table 2. . Summary of reported immune checkpoint inhibitors experience in patients with solid organ transplants.
Patient | Study | Transplant | Cancer | ICI agent | Rejection (Y/N) | Immunosuppression prior to ICI | Immunosuppression during ICI treatment | Outcome |
---|---|---|---|---|---|---|---|---|
1 | Lipson et al. | Kidney | MM | Ipilimumab | N | Prednisone/tacrolimus | Prednisone | Response |
2 | Lipson et al. | Kidney | MM | Ipilimumab | N | Prednisone/tacrolimus/mycophenolate | Prednisone | Response |
3 | Ranganath et al. | Liver | MM | Ipilimumab | N | Tacrolimus | Tacrolimus | POD |
4 | Morales et al. | Liver | MM | Ipilimumab | N | Rapamycin/mycophenolate | Rapamycin | Response |
5 | Jose et al. | Kidney | Metastatic Choroidal Melanoma | Ipilimumab | Y | Tacrolimus | Prednisolone | Not Reported |
6 | Herz et al. | Kidney | MM | Ipilimumab | N | Prednisone/tacrolimus | Prednisone/tacrolimus | POD |
Nivolumab (after ipilimumab) | ||||||||
7 | Spain et al. | Kidney | MM | Ipilimumab | N | Prednisone/tacrolimus | Prednisone | POD |
Nivolumab (after ipilimumab) | Y | Prednisone | Response | |||||
8 | Alhamad et al. | Kidney | Metastatic SCC of skin | Ipilimumab | N | Cyclosporine/prednisone | Prednisone | POD |
Nivolumab (after ipilimumab) | Y | Prednisone | Not reported | |||||
9 | Qin et al. | Heart | MM | Ipilimumab | N | Tacrolimus | Tacrolimus | POD |
Pembrolizumab (after ipilimumab) | ||||||||
10 | Grant et al. | Heart | MM | Pembrolizumab | N | Tacrolimus/mycophenolate | Tacrolimus/mycophenolate | POD |
11 | Ong et al. | Kidney | MM | Nivolumab | Y | Prednisone/tacrolimus/mycophenolate | Prednisone | Response |
12 | Lipson et al. | Kidney | Metastatic SCC of skin | Pembrolizumab | Y | Cyclosporine/prednisone | Prednisone | Response |
13 | Owonikoko et al. | Heart | Metastatic SCC of skin | Nivolumab | Y | Tacrolimus/sirolimus | Prednisone/tacrolimus | Not reported |
14 | Barnett et al. | Kidney | Metastatic Adenocarcinoma of the Duodenum | Nivolumab | N | Prednisone/tacrolimus/mycophenolate | Prednsione/sirolimus | Response |
15 | Boils et al. | Kidney | Stage IV NSCLC | Nivolumab | Y | Cyclosporine/prednisone | Reduced dose cyclosporine/prednisone | Not reported |
16 | Kittai et al. [68] | Kidney | Metastatic SCC of skin | Nivolumab | N | Prednisone/tacrolimus/mycophenolate | Prednisone/sirolimus | Response |
17 | Kittai et al. | Orthotopic Heart Transplant | Stage IV NSCLC | Nivolumab | N | Prednisone/cyclosporine/mycophenolate | Reduced dose cyclosporine/reduced dose mycophenolate | Response |
ICI: Immune checkpoint inhibitor; MM: Metastatic melanoma; N: No; NSCLC: Non-small-cell lung cancer; POD: Progression of disease; SCC: Squamous cell carcinoma; Y: Yes.