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IC50 values for inhibition of human and rat α6/α3β4 nAChRs by PeIA, PnIA, and TxIB
Values in parentheses indicate the 95% CI of the data obtained from at least four oocytes per IC50 determination.
| α-Ctx | IC50 |
|
|---|---|---|
| Human α6/α3β4 | Rat α6/α3β4 | |
| nm | ||
| PeIA | 9.9 (8.2–11.9) | 154 (143–166) |
| PnIA | 149 (135–164) | 8,456 (5,419–13,290) |
| TxIB | 402 (338–477) | >10,000 |
