Table 5.

IC₅₀ values for inhibition of human and rat α6/α3β4 nAChRs by analogs of PeIA

Values in parentheses indicate the 95% CI of the data obtained from four oocytes per IC₅₀ determination. Log(IC₅₀ ratio) = log(analog/PeIA).

α-Ctx	Human		Rat
	IC50	Log (IC50 ratio)	IC50	Log (IC50 ratio)
	nm		nm
PeIA	9.9 (8.2–11.9)a		154 (143–166)a
[P13O]PeIA	32.6 (28.2–37.7)	0.5	688 (540–876)	0.7
[P13A]PeIA	73.3 (66.8–80.5)	0.9	381 (317–456)	0.4
[P13Q]PeIA	34.0 (26.1–44.4)	0.5	8,231 (5,784–11,710)	1.7
[P13R]PeIA	188 (159–222)	1.3	51,780 (29,710–90,270)	2.5

^a Data from Table 1 shown for ease of comparison.