Table 2.
Trends in Clinical Parameters in Participants Treated for Tuberculosis, With Confirmed Tuberculosis, Possible Tuberculosis, and Not Treated for Tuberculosis
| No.a | Baseline | Week 2 | Week 4 | Week 8 | P b | ||
|---|---|---|---|---|---|---|---|
| C-reactive protein, mg/L | Treated for TB | 265 | 56.2 (17.6 to 114.2) | 13.0 (4.0 to 33.3) | 14.0 (5.0 to 28.4) | 8.6 (3.0 to 20.0) | <.0001 |
| Confirmed TB | 125 | 84.0 (45.8 to 128.3) | 15.8 (7.2 to 39.5) | 18.0 (7.0 to 35.7) | 8.0 (3.0 to 20.2) | <.0001 | |
| Possible TB | 140 | 30.4 (8.0 to 84.1) | 10.8 (3.0 to 26.8) | 9.6 (4.0 to 24.0) | 9.0 (3.0 to 20.0) | <.0001 | |
| Not treated for TB | 82 | 3.9 (2.0 to 10.0) | 3.0 (2.0 to 9.0) | 3.0 (2.0 to 10.1) | 3.4 (2.0 to 9.0) | .5 | |
| Weight, kg | Treated for TB | 270 | 56.8 (50.1 to 64.4) | 57.0 (50.6 to 64.9) | 57.9 (51.2 to 65.5) | 58.4 (52.3 to 65.8) | <.0001 |
| Confirmed TB | 128 | 55.6 (49.7 to 62.1) | 55.5 (50.2 to 62.1) | 56.6 (50.6 to 62.1) | 57.7 (52.5 to 63.5) | <.0001 | |
| Possible TB | 142 | 58.1 (50.5 to 66.0) | 58.9 (51.0 to 66.6) | 59.0 (51.9 to 66.8) | 59.9 (52.2 to 68.1) | <.0001 | |
| Not treated for TB | 82 | 59.9 (53.1 to 67.6) | 60.4 (53.9 to 68.2) | 61.0 (54.2 to 69.3) | 60.4 (54.6 to 69.8) | .4 | |
| Hemoglobin, g/dL | Treated for TB | 265 | 10.6 (9.2 to 12.1) | 10.6 (9.4 to 12.2) | 11.1 (9.8 to 12.4) | 11.7 (10.2 to 12.9) | <.0001 |
| Confirmed TB | 125 | 10.2 (8.8 to 11.7) | 10.4 (9.2 to 11.7) | 10.8 (9.7 to 12.3) | 11.7 (10.3 to 12.8) | <.0001 | |
| Possible TB | 140 | 11.1 (9.7 to 12.4) | 10.9 (9.6 to 12.4) | 11.2 (10.0 to 12.7) | 11.7 (10.0 to 13.0) | <.0001 | |
| Not treated for TB | 80 | 13.3 (11.4 to 14.4) | 13.0 (11.6 to 14.4) | 13.0 (11.3 to 14.3) | 13.2 (11.7 to 14.5) | .4 | |
| Karnofsky Performance Score | Treated for TB | 270 | 70 (60 to 80) | 70 (70 to 80) | 80 (70 to 80) | 90 (80 to 90) | <.0001 |
| Confirmed TB | 128 | 60 (50 to 70) | 70 (60 to 80) | 80 (70 to 80) | 80 (80 to 90) | <.0001 | |
| Possible TB | 142 | 70 (60 to 80) | 80 (70 to 80) | 80 (80 to 90) | 90 (80 to 90) | <.0001 | |
| Not treated for TB | 82 | 70 (70 to 80) | 80 (70 to 80) | 80 (70 to 80) | 80 (80 to 90) | <.0001 | |
| Symptom score ratio | Treated for TB | 270 | 0.0 (0.0 to 0.0) | 0.8 (0.6 to 1.0) | 1.0 (08. to 1.0) | 1.0 (1.0 to 1.0) | <.0001 |
| Confirmed TB | 128 | 0.0 (0.0 to 0.0) | 0.8 (0.6 to 1.0) | 0.9 (0.8 to 1.0) | 1.0 (0.9 to 1.0) | <.0001 | |
| Possible TB | 142 | 0.0 (0.0 to 0.0) | 0.8 (0.7 to 1.0) | 1.0 (0.8 to 1.0) | 1.0 (1.0 to 1.0) | <.0001 | |
| Not treated for TB | 82 | 0.0 (0.0 to 0.0) | 0.6 (0.3 to 0.8) | 0.8 (0.5 to 1.0) | 1.0 (0.7 to 1.0) | <.0001 |
Repeat baseline and on-treatment observations were obtained for 16 participants who started antituberculosis therapy after an initial period of observation. Values at different time points are medians with interquartile ranges in parentheses.
Abbreviation: TB, tuberculosis.
aNumber of participants contributing complete data set to model.
b P value for trend.