Table 4.

On-Treatment Performance Characteristics of Baseline to Week 2 Change in CRP in Predicting Death or Hospitalization at Percent Change Cutoff of ≤55%

	Treated for TB	Confirmed TB	Possible TB
No. of participants	295	137	158
No. who died or were hospitalized	14	5	9
Sensitivity	0.92 (0.69 to 0.99)	1.0 (0.57 to 1.0)	0.89 (0.57 to 0.98)
Specificity	0.59 (0.53 to 0.64)	0.71 (0.62 to 0.78)	0.48 (0.40 to 0.56)
Youden’s index	0.52	0.71	0.37
Positive predictive value	0.10 (0.08 to 0.12)	0.1 (0.09 to 0.14)	0.09 (0.07: 0.12)
Negative predictive value	0.99 (0.96 to 1.0)	1.0 (– to –)	0.99 (0.92 to 1.0)
Positive likelihood ratio	2.2 (1.6 to 2.7)	3.4 (1.8 to 4.5)	1.7 (1.1 to 2.1)
Negative likelihood ratio	0.12 (0.02 to 0.53)	0.0 (0.0 to 0.62)	0.23 (0.04 to 0.92)
Odds ratio	18.5 (3.0 to 111.8)	+∞ (3.0 to +∞)	7.5 (1.2 to 47.2)

Figures in parentheses are 95% confidence intervals.

Abbreviations: CRP, C-reactive protein, TB, tuberculosis.