Table 2.
Novel Markers of Classical Pituitary Populations
| Log2 Fold Change |
Adjusted P Value |
|
|---|---|---|
| Somatotrope cluster | ||
| Pappa2 | 3.17 | 2.49 × 10−22 |
| Gh | 3.05 | 6.16 × 10−22 |
| Ceacam10 | 2.74 | 2.57 × 10−17 |
| Ghrhr | 2.57 | 2.00 × 10−16 |
| Tcerg1l | 2.67 | 5.12 × 10−16 |
| Cabp2 | 3.00 | 7.94 × 10−16 |
| Wnt10a | 2.57 | 8.39 × 10−16 |
| RP24-294M17.1 | 2.89 | 2.29 × 10−15 |
| Mmp7 | 3.23 | 3.40 × 10−15 |
| Gm43569 | 2.95 | 5.85 × 10−15 |
| Sstr5 | 2.64 | 2.47 × 10−14 |
| Sstr2 | 2.39 | 1.02 × 10−11 |
| Rxrg | 2.10 | 1.41 × 10−11 |
| Rad18 | 1.27 | 5.68 × 10−5 |
| Lactotrope cluster | ||
| Prl | 5.10 | 3.30 × 10−69 |
| Agtr1a | 4.90 | 2.71 × 10−60 |
| Syndig1 | 5.27 | 1.29 × 10−55 |
| Angpt1 | 4.75 | 1.29 × 10−55 |
| Edil3 | 4.55 | 1.38 × 10−52 |
| 6030419C18Rik | 4.68 | 2.59 × 10−52 |
| Hepacam2 | 4.41 | 1.09 × 10−51 |
| Cilp | 4.84 | 2.31 × 10−48 |
| Akr1c14 | 5.01 | 1.80 × 10−44 |
| Gpr83 | 5.33 | 2.95 × 10−43 |
| Gonadotrope cluster | ||
| Lhb | 7.82 | 8.01 × 10−99 |
| Tgfbr3l | 7.72 | 5.60 × 10−97 |
| Fshb | 7.49 | 2.50 × 10−90 |
| Gnrhr | 7.78 | 5.79 × 10−90 |
| Cga | 6.78 | 1.30 × 10−73 |
| Spp1 | 6.91 | 6.99 × 10−71 |
| Grem1 | 7.43 | 6.08 × 10−59 |
| Nr0b1 | 6.87 | 1.14 × 10−57 |
| Speer4e | 7.55 | 5.15 × 10−57 |
| Rarres1 | 7.26 | 1.61 × 10−55 |
| Nr5a1 | 6.04 | 2.69 × 10−50 |
| Foxp2 | 5.16 | 4.91 × 10−33 |
| Corticotrope cluster | ||
| Crhr1 | 7.59 | 6.98 × 10−50 |
| Gpc5 | 8.04 | 2.27 × 10−40 |
| Tbx19 | 6.52 | 1.99 × 10−36 |
| Tnnt1 | 7.12 | 3.89 × 10−36 |
| Tnni3 | 7.41 | 6.26 × 10−28 |
| Gm15543 | 7.21 | 1.05 × 10−27 |
| Cplx3 | 7.51 | 1.05 × 10−27 |
| Egr4 | 7.47 | 6.98 × 10−24 |
| Cdh8 | 7.71 | 2.61 × 10−23 |
| Galnt9 | 6.51 | 2.61 × 10−23 |
| Pomc | 3.06 | 3.34 × 10−4 |
| Melanotrope cluster | ||
| Pomc | 7.23 | 5.80 × 10−51 |
| Oacyl | 7.16 | 3.01 × 10−38 |
| Pax7 | 7.37 | 3.12 × 10−31 |
| Esm1 | 6.11 | 1.95 × 10−21 |
| Pkib | 5.77 | 2.29 × 10−21 |
| Pcsk2 | 5.46 | 2.53 × 10−21 |
| Gulo | 6.97 | 3.38 × 10−20 |
| Megf11 | 5.86 | 5.55 × 10−18 |
| Rbfox3 | 5.77 | 2.60 × 10−17 |
| Scn2a1 | 5.30 | 2.92 × 10−15 |
| Thyrotrope cluster | ||
| Tshb | 8.42 | 1.56 × 10−6 |
| Trhr | 7.86 | 6.12 × 10−4 |
| Dio2 | 6.30 | 1.85 × 10−3 |
| Stem cell cluster | ||
| Cyp2f2 | 9.60 | 9.78 × 10−122 |
| Lcn2 | 9.39 | 1.33 × 10−106 |
| Mia | 8.72 | 2.68 × 10−103 |
| Aldh3a1 | 9.30 | 7.07 × 10−93 |
| Aldh1a2 | 8.42 | 2.50 × 10−90 |
| Cpxm2 | 8.38 | 3.43 × 10−87 |
| Rbpms | 7.77 | 1.08 × 10−84 |
| Gm266 | 8.49 | 5.21 × 10−84 |
| Cdh26 | 11.46 | 7.29 × 10−83 |
| Aqp3 | 9.08 | 1.53 × 10−81 |
| Aqp4 | 9.77 | 1.06 × 10−75 |
| Sox2 | 6.86 | 1.78 × 10−62 |
| Proliferating Pou1f1 cluster | ||
| Pbk | 7.92 | 6.98 × 10−61 |
| Spc25 | 7.83 | 6.49 × 10−60 |
| Cdca3 | 7.24 | 2.95 × 10−52 |
| Birc5 | 7.29 | 9.17 × 10−52 |
| Cenpf | 7.57 | 4.29 × 10−51 |
| Ube2c | 7.68 | 1.14 × 10−50 |
| Hmmr | 7.86 | 4.76 × 10−50 |
| Top2a | 7.56 | 2.17 × 10−49 |
| Ckap2l | 7.60 | 3.93 × 10−48 |
| Ccnb1 | 7.77 | 7.30 × 10−47 |
| Cdk1 | 6.99 | 5.61 × 10−46 |
| Ccna2 | 6.96 | 8.84 × 10−44 |
| Ccnb2 | 6.80 | 1.23 × 10−39 |
Log2 fold change values and Benjamini–Hochberg adjusted P values for the somatotrope, lactotrope, corticotrope, melanotrope, thyrotrope, Sox2 stem cell, and proliferating Pou1f1 cell clusters as labeled in Fig. 4A. Many novel candidate genes are more significantly enriched than the cell type–identifying hormones. Rows in bold type indicate novel genes of that cell type.