Table 1.
Geometric (arithmetic) mean counts of live ticks and percent reduction from baseline in each group
| Visit | Mean | Reduction (%) | t-statistic (tdf) |
P-value (Pr > t) |
Mean | Reduction (%) | t-statistic (tdf) |
P-value (Pr > t) |
|---|---|---|---|---|---|---|---|---|
| Per protocol population | ||||||||
| Fluralaner + moxidectin (n = 152) | Fipronil (n = 77) | |||||||
| 1 | 2.59 (3.67) | – | 2.17 (2.61) | – | ||||
| 2 | 0.05 (0.09) | 98.3 (97.7) | t(200.37) = 26.6 | <0.0001 | 0.12 (0.21) | 94.4 (92.0) | t(152) = 17.9 | <0.0001 |
| 3 | 0.07 (0.16) | 97.2 (95.7) | t(228.96) = 24.9 | <0.0001 | 0.11 (0.23) | 94.9 (91.0) | t(152) = 17.6 | <0.0001 |
| 4 | 0.07 (0.15) | 97.3 (95.9) | t(228.17) = 25.0 | <0.0001 | 0.16 (0.23) | 92.7 (91.0) | t(144.27) = 17.5 | <0.0001 |
| 5 | 0.05 (0.09) | 97.9 (97.5) | t(199.31) = 26.5 | <0.0001 | 0.07 (0.10) | 97.0 (96.0) | t(119.53) = 21.0 | <0.0001 |
| Intent to treat population | ||||||||
| Fluralaner + moxidectin (n = 171) | Fipronil (n = 86) | |||||||
| 1 | 2.54 (3.61) | – | 2.22 (2.70) | – | ||||
| 2 | 0.04 (0.08) | 98.4 (97.9) | t(219.73) = 28.1 | <0.0001 | 0.17 (0.34) | 92.2 (87.6) | t(170) = 16.0 | <0.0001 |
| 3 | 0.08 (0.15) | 96.9 (95.6) | t(255.62) = 25.9 | <0.0001 | 0.15 (0.35) | 93.2 (87.0) | t(169) = 16.1 | <0.0001 |
| 4 | 0.07 (0.14) | 97.3 (96.0) | t(252.87) = 26.2 | <0.0001 | 0.15 (0.22) | 93.4 (92.0) | t(156.24) = 18.6 | <0.0001 |
| 5 | 0.06 (0.10) | 97.6 (97.1) | t(230.92) = 27.2 | <0.0001 | 0.07 (0.11) | 96.9 (96.0) | t(132.43) = 21.6 | <0.0001 |