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. 2018 Nov 19;11:598. doi: 10.1186/s13071-018-3175-z

Table 4.

Percent of households with at least one cat initially infested with at least two fleas that were free of fleas at subsequent visits

Treatment group Households free of fleas (%)
Visit 2 Visit 3 Visit 4 Visit 5
Per protocol population
 Fluralaner + moxidectin 95.6 94.1 95.6 93.3
 Fipronil 76.7 69.9 68.5 60.3
 Lower 97.5% one-sided confidence limita 0.0929 0.1388 0.1673 0.2190
P-value for non-inferiorityb <0.0001 <0.0001 <0.0001 <0.0001
 Intent to treat population
 Fluralaner + moxidectin 94.7 93.4 96.0 93.9
 Fipronil 75.0 70.2 69.5 61.7
 Lower 97.5% one-sided confidence limita 0.1046 0.1337 0.1682 0.2169
P-value for non-inferiorityb <0.0001 <0.0001 <0.0001 <0.0001

aLower 97.5% one-sided confidence limit was well above the non-inferiority limit of -0.15. If the lower confidence limit was above -0.15, non-inferiority was concluded. If the lower confidence limit was above 0, superiority was concluded

bFarrington-Manning method