Table 4.
Treatment group | Households free of fleas (%) | |||
---|---|---|---|---|
Visit 2 | Visit 3 | Visit 4 | Visit 5 | |
Per protocol population | ||||
Fluralaner + moxidectin | 95.6 | 94.1 | 95.6 | 93.3 |
Fipronil | 76.7 | 69.9 | 68.5 | 60.3 |
Lower 97.5% one-sided confidence limita | 0.0929 | 0.1388 | 0.1673 | 0.2190 |
P-value for non-inferiorityb | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
Intent to treat population | ||||
Fluralaner + moxidectin | 94.7 | 93.4 | 96.0 | 93.9 |
Fipronil | 75.0 | 70.2 | 69.5 | 61.7 |
Lower 97.5% one-sided confidence limita | 0.1046 | 0.1337 | 0.1682 | 0.2169 |
P-value for non-inferiorityb | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
aLower 97.5% one-sided confidence limit was well above the non-inferiority limit of -0.15. If the lower confidence limit was above -0.15, non-inferiority was concluded. If the lower confidence limit was above 0, superiority was concluded
bFarrington-Manning method