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. 2018 Nov 19;6:125. doi: 10.1186/s40478-018-0629-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Riluzole and Ivermectin modulate HSR in sod1 and C9orf72 zebrafish. (a) Treatment with either 10 μM riluzole or 1 μM ivermectin from 2 to 5 dpf resulted in a significant reduction in DsRed fluorescence in sod1 zebrafish, as compared to DMSO treatment. N = 30 riluzole treated, 23 ivermectin treated and 43 DMSO treated individual zebrafish. (b) Treatment with either 10 μM riluzole or 1 μM ivermectin from 2 to 5 dpf resulted in a significant reduction in DsRed fluorescence in C9orf72 zebrafish (2.2–7 line), as compared to DMSO treatment. N = 34 riluzole treated, 34 ivermectin treated and 33 DMSO treated individual zebrafish. All data are shown as mean +/− standard deviation; *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001