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. 2018 Nov 19;11:93. doi: 10.1186/s13048-018-0468-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Luteolin suppressed cell invasion and enhanced cisplatin-induced suppression of invasion in CAOV3/DDP cells. Invasion ability of CAOV3/DDP cells of indicated treatments was measured using Matrigel invasion assay. a The image of invaded cells (magnification,× 200); b Numbers of invaded cells in each group of three independent experiments. ** P < 0.01, *** P < 0.001, vs. control; ### P < 0.001 vs. cisplatin. CDDP: cisplatin. CDDP combined with luteolin (50, 100 μM) showed a synergistic inhibitory effect on the invasion of CAOV3/DDP cells (Q = 1.06 ± 0.02 and 1.03 ± 0.007, respectively, > 1, P < 0.05 and P < 0.01, respectively)