Fig. 7.

Luteolin in combination with cisplatin enhanced apoptosis in vivo. Apoptosis of tumor sections were detected by TUNEL assay. a Representative images of apoptotic cells in each group (apoptotic cells in green and the cell nuclei in blue). b The tumor cell apoptosis rates of 8 groups were analyzed. * P < 0.05, ** P < 0.01, vs. control; # P < 0.05 vs. cisplatin. CDDP: cisplatin. CDDP combined with luteolin (20 mg, 40 mg) exhibited a synergistic effect on the apoptosis induction of xenograft tumor (Q = 1.73 ± 0.03 and 2.95 ± 0.16, respectively, > 1, P < 0.01 and P < 0.01, respectively)