Table 2.

Luteolin increased the sensitivity of CAOV3/DDP cells to cisplatin. The Q value was calculated to evaluate the effect of the combination of the two drugs. The inhibition rates were measured by CCK-8 assay. CDDP combined with luteolin (100 μM) showed a synergistic inhibitory effect on the proliferation of CAOV3/DDP cells (Q = 1.22 ± 0.04, > 1, P < 0.01). The data were expressed as the mean ± S.D. in triplicate

Drugs	Inhibition rate (%)	Q value
Luteolin (100 μM)	69.1 ± 0.55
Luteolin (50 μM)	42.0 ± 1.20
Luteolin (10 μM)	−1.5 ± 6.26
CDDP (2 μg/ml)	30.2 ± 4.54
Luteolin (100 μM) + CDDP (2 μg/ml)	95.7 ± 0.24	1.22 ± 0.04
Luteolin (50 μM) + CDDP (2 μg/ml)	64.3 ± 1.22	1.08 ± 0.06
Luteolin (10 μM) + CDDP (2 μg/ml)	37.9 ± 3.02	1.36 ± 0.41