Table 3. The entire combinatorial scheme of E, I, PD and A and the and the main effect on colo-205 CRC cell line.
| colo-205 | treatment | viabillity | autophagy | apoptosis | colo-205 | treatment | viabillity | autophagy | apoptosis |
|---|---|---|---|---|---|---|---|---|---|
| E | C | NC | NC | NC | PD | PD | + | PR | NC |
| P | NC | PR | NC | PD+E | PD+C | + | PR | NC | |
| I | NI | NC | NC | NC | PD+P | + | PR | NC | |
| PE | NC | PR | NC | PD+I | PD+NI | + | PR | NC | |
| IPI | NC | NC | NC | PD+PE | + | PR | NC | ||
| E+I | C+NI | NC | PR | NC | PD+IPI | + | PR | NC | |
| C+PE | NC | NC | NC | A | 3-MA | + | IN | NC | |
| C+IPI | NC | NC | NC | A+PD | 3-MA+PD | + | IN | PR | |
| P+NI | NC | NC | NC | A+PD+E | 3-MA+PD+C | ++ | IN | PR | |
| P+PE | NC | NC | NC | 3-MA+PD+P | ++ | IN | PR | ||
| P+IPI | NC | NC | NC | A+PD+I | 3-MA+PD+NI | ++ | IN | PR | |
| A | 3-MA | + | IN | NC | 3-MA+PD+PE | ++ | IN | PR | |
| A+E | 3-MA+C | + | IN | NC | 3-MA+PD+IPI | ++ | IN | PR | |
| 3-MA+P | + | IN | NC | A | HCQ | + | IN | NC | |
| A+I | 3-MA+NI | + | IN | NC | A+E | HCQ+C | + | IN | NC |
| 3-MA+PE | + | IN | NC | HCQ+P | + | IN | NC | ||
| 3-MA+IPI | + | IN | NC | A+I | HCQ+NI | + | IN | NC | |
| A+E+I | 3-MA+C+NI | + | IN | NC | HCQ+PE | + | IN | NC | |
| 3-MA+C+PE | + | IN | NC | HCQ+IPI | + | IN | NC | ||
| 3-MA+C+IPI | + | IN | NC | A+PD | HCQ+PD | + | IN | PR | |
| 3-MA+P+NI | + | IN | NC | A+PD+E | HCQ+PD+C | ++ | IN | PR | |
| 3-MA+P+PE | + | IN | NC | HCQ+PD+P | ++ | IN | PR | ||
| 3-MA+P+IPI | + | IN | NC | A+PD+I | HCQ+PD+NI | ++ | IN | PR | |
| HCQ+PD+PE | ++ | IN | PR | ||||||
| HCQ+PD+IPI | ++ | IN | PR |
NC: not changed; IN: Inhibition; PR: present; +: <20% protein vs control; ++: <40%