Table 3.
Pharmacokinetic parameters for eight compounds in plasma after oral administration of YCHT.
| Pharmacokinetic Parameter | t 1/2 (h) | Cmax (μg/L) | Tmax (h) | AUC0–t (ug/L∗h) | AUC0–∞ (ug/L∗h) | MRT0–t (h) | MRT0–∞ (h) | CLz/F (L/h/kg) | Fr (%) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Scoparone | Control | 2.14 ± 0.71 | 939.32 ± 112.19 | 0.54 ± 0.10 | 2282.77 ± 390.03 | 2347.92 ± 428.69 | 3.19 ± 0.16 | 3.51 ± 0.14 | 4.42 ± 0.82 | 227.64 |
| Model | 1.58 ± 0.13 | 1767.17 ± 106.78∗∗ | 0.33 ± 0.13∗ | 5196.54 ± 513.37∗∗ | 5197.06 ± 513.33∗∗ | 3.94 ± 0.26∗∗ | 3.95 ± 0.26∗∗ | 1.96 ± 0.23∗∗ | ||
| Scopoletin | Control | 3.62 ± 3.85 | 3.53 ± 0.67 | 0.19 ± 0.04 | 5.86 ± 0.50 | 7.41 ± 2.53 | 4.40 ± 0.44 | 6.90 ± 4.20 | 70.72 ± 16.41 | 123.38 |
| Model | 2.20 ± 0.82 | 3.34 ± 1.19 | 0.13 ± 0.05∗ | 7.23 ± 1.84 | 7.83 ± 2.00 | 4.81 ± 0.43 | 5.56 ± 0.63 | 66.11 ± 16.51 | ||
| Geniposide | Control | 3.55 ± 0.38 | 751.37 ± 47.72 | 0.33 ± 0.13 | 1940.63 ± 210.72 | 1958.65 ± 206.96 | 4.57 ± 0.41 | 4.80 ± 0.47 | 8.84 ± 0.92 | 257.67 |
| Model | 6.59 ± 2.46∗ | 1863.84 ± 108.53∗∗ | 0.58 ± 0.20∗ | 5000.36 ± 755.13∗∗ | 5223.83 ± 746.92∗∗ | 4.68 ± 0.57 | 5.99 ± 0.61∗∗ | 3.34 ± 0.49∗∗ | ||
| Aloe-emodin | Control | 2.26 ± 1.15 | 15.18 ± 1.68 | 0.54 ± 0.19 | 54.61 ± 6.50 | 60.86 ± 6.68 | 3.34 ± 0.12 | 4.33 ± 0.84 | 44.24 ± 5.84 | 281.30 |
| Model | 1.98 ± 0.71 | 36.68 ± 3.09∗∗ | 0.58 ± 0.30 | 153.62 ± 18.13∗∗ | 158.71 ± 19.26∗∗ | 3.68 ± 0.34∗ | 4.07 ± 0.40 | 16.98 ± 2.15∗∗ | ||
| Rhein | Control | 4.64 ± 2.14 | 663.62 ± 50.31 | 0.33 ± 0.13 | 2031.40 ± 385.58 | 2074.39 ± 387.77 | 4.79 ± 0.36 | 5.38 ± 0.49 | 4.92 ± 1.11 | 268.45 |
| Model | 3.62 ± 1.97 | 1759.02 ± 140.49∗∗ | 0.54 ± 0.19∗ | 5453.29 ± 1202.14∗∗ | 5518.78 ± 1256.46∗∗ | 4.38 ± 0.41 | 4.67 ± 0.65 | 1.87 ± 0.43∗∗ | ||
| Emodin | Control | 3.33 ± 1.67 | 3.51 ± 0.59 | 0.20 ± 0.17 | 10.41 ± 0.83 | 12.06 ± 1.53 | 4.94 ± 0.26 | 6.65 ± 1.99 | 69.69 ± 8.45 | 112.01 |
| Model | 3.64 ± 0.79 | 3.89 ± 0.89 | 0.17 ± 0.05 | 11.66 ± 2.70 | 13.49 ± 2.43 | 4.83 ± 0.25 | 6.64 ± 0.78 | 63.22 ± 11.47 | ||
| Chrysophanol | Control | 2.00 ± 0.23 | 34.48 ± 4.99 | 0.63 ± 0.26 | 99.34 ± 10.12 | 103.57 ± 10.09 | 2.93 ± 0.16 | 3.34 ± 0.21 | 21.80 ± 2.08 | 142.23 |
| Model | 3.12 ± 1.74 | 37.61 ± 6.51 | 0.88 ± 0.35 | 141.29 ± 27.92∗∗ | 148.47 ± 25.04∗∗ | 3.43 ± 0.40∗ | 4.20 ± 0.77∗ | 15.42 ± 2.38∗∗ | ||
| Physcione | Control | 2.65 ± 0.99 | 8.45 ± 1.61 | 1.25 ± 0.27 | 21.05 ± 4.04 | 22.44 ± 5.54 | 2.88 ± 0.25 | 3.54 ± 0.49 | 26.99 ± 5.66 | 213.68 |
| Model | 3.06 ± 2.37 | 9.99 ± 2.86 | 2.58 ± 1.11∗ | 44.98 ± 13.92∗∗ | 48.47 ± 12.74∗∗ | 4.07 ± 0.40∗∗ | 5.26 ± 1.30∗ | 12.63 ± 3.12∗∗ | ||
∗ p<0.05 compared with control rats.
∗∗ p<0.01 compared with control rats.