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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Curr Opin Physiol. 2018 Mar 26;3:110–115. doi: 10.1016/j.cophys.2018.03.006

Figure 2.

Figure 2

Different roles played by Mfn2 in mitochondrial fusion, motility, and mitophagy and how they have been experimentally modulated. Mfn2 roles in cell death and cardiac development are not reviewed here and are included for completeness. Modulation of mitochondrial fusion and trafficking by Mfn agonist peptides and small molecule peptidomimetics is from Refs. [30•,31••]. Regulation of mitophagy and perinatal cardiac metabolic transitions by Mfn2 mutants with modified T111 and S442 PINK1 phosphorylation sites (Mfn2 AA and EE) is described in Refs. [3••,9].